Native Allergens

Native allergens are essential tools in allergy research and diagnostic development, providing biologically relevant representations of real-world allergen exposure.

At Creative BioMart, we offer a comprehensive portfolio of natural allergen extracts and purified native allergens derived from diverse sources, including dust mites, foods, pollens, animals, and fungi. Our products are widely used in IgE-binding studies, immunoassay development, and allergen standardization research.

Native Allergen Product List

What Are Native Allergens?

Native allergens are allergenic proteins or complex extracts obtained directly from natural biological sources such as pollen, food materials, animal dander, mites, and fungi.

Unlike recombinant allergens, native allergens retain the full spectrum of allergenic components, including isoforms, conformational epitopes, and natural post-translational modifications. This makes them particularly valuable for studying complex immune responses and real exposure scenarios.

Native vs Recombinant Allergens

Understanding the differences between native and recombinant allergens is critical when selecting the right materials for your research.

When to use native allergens?

Use native allergens when studying whole allergen exposure, IgE cross-reactivity, or extract-based diagnostics.

Figure 1. A Holistic View of Native Allergens: Sources, Molecular Forms, and Research/Diagnostic Applications. (Creative BioMart)

Explore Our Native Allergen Categories

Dust Mite Allergens

Dust mites are among the most significant indoor allergens associated with respiratory diseases such as asthma and allergic rhinitis.

Available sources include:

• Dermatophagoides pteronyssinus (Der p)
• Dermatophagoides farinae (Der f)
• Storage mites (Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro)

Applications:

• Airway allergy research
• IgE sensitization profiling
• Diagnostic assay development

Food Allergens

Food allergens play a central role in IgE-mediated food allergies and are critical for both research and regulatory testing.

Representative allergens:

• Peanut (Ara h 1, Ara h 2, Ara h 3, Ara h 6)
• Milk (Bos d 5, Bos d 6, Bos d 8)
• Egg (Gal d 1-5)
• Tree nuts (almond, cashew, walnut, pistachio)

Applications:

• Food allergy diagnostics
• Allergen labeling and safety assessment
• Epitope and stability studies

Pollen Allergens

Plant and pollen allergens are major contributors to seasonal allergic rhinitis and environmental allergy studies.

Includes:

• Ragweed (Ambrosia elatior)
• Timothy grass (Phleum pratense)
• Birch, mugwort, ribwort, acacia
• Eucalyptus pollen

Applications:

• Seasonal allergy modeling
• Environmental exposure studies

Animal-Derived Allergens

Animal allergens are commonly associated with occupational and domestic exposure.

Includes:

• Cat dander
• Dog dander
• Horse serum allergens

Fungal & Environmental Allergens

Fungal allergens and environmental allergens are critical for studying airborne and occupational allergies.

Includes:

• Aspergillus fumigatus
• Alternaria alternata
• Cockroach allergens (Blattella germanica, Periplaneta americana)
• Bee venom (Apis mellifera)

Featured Native Allergens

Some of the most widely used native allergens in research include:

• Der p 1 / Der f 1 – Major dust mite allergens for respiratory studies
• Ara h 2 – Key peanut allergen with strong IgE reactivity
• Bos d 5 (β-lactoglobulin) – Dominant milk allergen
• Gal d 1 (Ovomucoid) – Heat-stable egg allergen

These allergens are frequently used in diagnostic assay development and immunological studies.

Applications of Natural Allergen Extracts

Our native allergens support a wide range of applications, including:

• IgE binding assays (ELISA, Western blot, ImmunoCAP development)
• Allergy diagnostic research and assay validation
• Skin prick test (SPT) development
• Allergen standardization and potency studies
• Cross-reactivity and epitope analysis
• Environmental and food allergen exposure modeling

These applications require biologically relevant allergen compositions, which native extracts uniquely provide.

Why Choose Our Native Allergens?

• Extensive allergen library across major categories
• High biological relevance and natural composition
• Validated IgE reactivity for research applications
• Flexible formats (extracts, purified proteins, labeled allergens)
• Dedicated scientific support and customization services

Quality Control & Characterization

All native allergens are subjected to rigorous quality control to ensure reliability and reproducibility:

• Protein profiling (SDS-PAGE, HPLC)
• IgE-binding activity validation
• Allergen composition analysis
• Batch-to-batch consistency control
• Source traceability

Custom Native Allergen Extraction Services

In addition to off-the-shelf products, we offer custom allergen solutions tailored to your research needs:

• Custom allergen extraction from specific biological sources
• Purification of target allergenic proteins
• Protein labeling (biotin, fluorescent tags)
• Bulk production and scale-up

Frequently Asked Questions

Looking for high-quality native allergen extracts for your research or diagnostic development? Our experts can help you identify the most suitable allergen source, format, and purity level for your application. Contact us or request a quote today.

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