What is House Dust Mite Allergen

House dust mites are microscopic arachnids that thrive in warm and humid environments, particularly in household dust. These seemingly harmless creatures become significant health concerns when their excretions and body fragments become airborne, triggering allergic reactions in sensitive individuals. At the heart of these allergic responses lie house dust mite allergen proteins, which belong to the molecular family of proteins crucially responsible for inducing immune responses.

Composition and Classification of House Dust Mite Allergen Proteins

House dust mite allergen proteins primarily include Der p 1 and Der p 2 from the Dermatophagoides pteronyssinus species, as well as Der f 1 and Der f 2 from Dermatophagoides farinae. These proteins are categorized under the cysteine protease and lipid-binding protein families, respectively. Der p 1 and Der f 1 are particularly noteworthy as major allergens, with Der p 1 often regarded as one of the most potent allergens among all house dust mite species.

Structurally, these allergens possess unique characteristics. Der p 1, for instance, exhibits a characteristic structure with an active site containing a catalytic triad. Der f 1, on the other hand, is a lipid-binding protein with a hydrophobic pocket, allowing it to interact with lipids in the environment. Understanding the structural nuances of these allergen proteins is crucial for deciphering their allergenic potential and developing targeted interventions.

Our Featured House Dust Mite Allergens

Cat.No.	Product Name	Species	Source	Tag
ra-3083AM	Recombinant Der f 1	Dermatophagoides farinae (American house dust mite)	HEK293 Cells	His
na-3083AP	Native Purified Der f 1	D. farinae	D. farinae
ra-3083AE	Recombinant Der f 1	Dermatophagoides farinae	E.coli
ra-3083A	Recombinant Der f 1	Dermatophagoides farinae (American house dust mite)	Yeast	His
ra-3083AB	Recombinant Der f 1, Biotin Labeled	Dermatophagoides farinae (American house dust mite)	Yeast	His
ra-3092A	Recombinant Der f 10	Dermatophagoides farinae (American house dust mite)	E.coli	His-Sumo
ra-3092AB	Recombinant Der f 10, Biotin Labeled	Dermatophagoides farinae (American house dust mite)	E.coli	His-Sumo
ra-3093A	Recombinant Der f 11	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3094A	Recombinant Der f 13	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3096A	Recombinant Der f 14	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3097A	Recombinant Der f 15	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3098A	Recombinant Der f 16	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3099A	Recombinant Der f 17	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3100A	Recombinant Der f 18	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3084AY	Recombinant Der f 2	Dermatophagoides	Yeast
ra-3084A	Recombinant Der f 2	American house dust mite	E.coli	His
ra-3084AB	Recombinant Der f 2, Biotin Labeled	American house dust mite	E.coli	His
ra-3084AYB	Recombinant Der f 2, Biotin Labeled	Dermatophagoides	Yeast
ra-3101A	Recombinant Der f 20	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3102A	Recombinant Der f 21	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3103A	Recombinant Der f 22	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3104A	Recombinant Der f 23	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3105A	Recombinant Der f 24	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3106A	Recombinant Der f 25	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3107A	Recombinant Der f 26	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3108A	Recombinant Der f 27	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3109A	Recombinant Der f 28	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3110A	Recombinant Der f 29	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3085A	Recombinant Der f 3	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3111A	Recombinant Der f 30	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3112A	Recombinant Der f 31	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3113A	Recombinant Der f 32	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3115A	Recombinant Der f 33	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3114A	Recombinant Der f 34	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3116A	Recombinant Der f 35	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3117A	Recombinant Der f 36	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3118A	Recombinant Der f 37	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3119A	Recombinant Der f 38	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3120A	Recombinant Der f 39	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3086A	Recombinant Der f 4	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3087A	Recombinant Der f 5	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3089A	Recombinant Der f 6	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3091A	Recombinant Der f 7	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3095A	Recombinant Der f 8	Dermatophagoides farinae (American house dust mite)	E.coli or Yeast	His
ra-3121A	Recombinant Der m 1	Dermatophagoides microceras (House dust mite)	E.coli or Yeast	His
ra-3122AE	Recombinant Der p 1	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3122AM	Recombinant Der p 1	Dermatophagoides pteronyssinus (European house dust mite)	HEK293 Cells	His
ra-3122AB	Recombinant Der p 1, Biotin Labeled	Dermatophagoides pteronyssinus (European house dust mite)	Yeast	His
ra-3122AEB	Recombinant Der p 1, Biotin Labeled	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3122A	Recombinant Der p 1	Dermatophagoides pteronyssinus (European house dust mite)	Mammalian cells
ra-3131A	Recombinant Der p 10	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3131AB	Recombinant Der p 10, Biotin Labeled	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3131A1	Recombinant Der p 10	Dermatophagoides pteronyssinus (European house dust mite)	E.coli
ra-3132AB	Recombinant Der p 11, Biotin Labeled	European house dust mite	E.coli	N/A
ra-3132A	Recombinant Der p 11	European house dust mite	E.coli	N/A
ra-3133A	Recombinant Der p 13	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3134A	Recombinant Der p 14	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3135A	Recombinant Der p 15	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3136A	Recombinant Der p 18	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3123AY	Recombinant Der p 2	Dermatophagoides pteronyssinus	Yeast
ra-3123AB	Recombinant Der p 2, Biotin Labeled	European house dust mite	E.coli	His
ra-3123A	Recombinant Der p 2	European house dust mite	E.coli	His
ra-3123AYB	Recombinant Der p 2, Biotin Labeled	Dermatophagoides pteronyssinus	Yeast
ra-3137A	Recombinant Der p 20	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3138AB	Recombinant Der p 21, Biotin Labeled	European house dust mite	E.coli	His
ra-3138A	Recombinant Der p 21	European house dust mite	E.coli	His
ra-3139A	Recombinant Der p 23	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3139AB	Recombinant Der p 23, Biotin Labeled	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3139AM	Recombinant Der p 23	Dermatophagoides pteronyssinus (European house dust mite)	HEK293 Cells	His
ra-3140A	Recombinant Der p 24	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3141A	Recombinant Der p 25	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3142A	Recombinant Der p 26	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3143A	Recombinant Der p 28	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3144A	Recombinant Der p 29	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3124AE	Recombinant Der p 3	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3124AB	Recombinant Der p 3, Biotin Labeled	European house dust mite	Yeast	His
ra-3124A	Recombinant Der p 3	European house dust mite	Yeast	His
ra-3124AEB	Recombinant Der p 3, Biotin Labeled	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3145A	Recombinant Der p 30	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3146A	Recombinant Der p 31	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3147A	Recombinant Der p 32	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3148A	Recombinant Der p 33	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3149A	Recombinant Der p 36	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3150A	Recombinant Der p 37	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3151A	Recombinant Der p 38	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3125AB	Recombinant Der p 4, Biotin Labeled	European house dust mite	E.coli	His
ra-3125A	Recombinant Der p 4	European house dust mite	E.coli	His
ra-3126A	Recombinant Der p 5	Dermatophagoides pteronyssinus (European house dust mite)	E.coli	His
ra-3127A	Recombinant Der p 6	Dermatophagoides pteronyssinus	E.coli
ra-3127AB	Recombinant Der p 6, Biotin Labeled	Dermatophagoides pteronyssinus	E.coli
ra-3128AB	Recombinant Der p 7, Biotin Labeled	European house dust mite	E.coli	His
ra-3128A	Recombinant Der p 7	European house dust mite	E.coli	His
ra-3129AB	Recombinant Der p 8, Biotin Labeled	European house dust mite	E.coli	His
ra-3129A	Recombinant Der p 8	European house dust mite	E.coli	His
ra-3130A	Recombinant Der p 9	Dermatophagoides pteronyssinus (European house dust mite)	E.coli or Yeast	His
ra-3157A	Recombinant Eur m 1	Euroglyphus maynei (House dust mite)	E.coli or Yeast	His
ra-3161A	Recombinant Eur m 14	Euroglyphus maynei (House dust mite)	E.coli or Yeast	His
ra-3158AB	Recombinant Eur m 2, Biotin Labeled	Euroglyphus maynei	E.coli
ra-3158A	Recombinant Eur m 2	Euroglyphus maynei	E.coli
ra-3159A	Recombinant Eur m 3	Euroglyphus maynei (House dust mite)	E.coli or Yeast	His
ra-3160A	Recombinant Eur m 4	Euroglyphus maynei (House dust mite)	E.coli or Yeast	His
na-3083ABL	House Dust Mite Extract, Biotinylated	Dermatophagoides farinae	D. farinae
na-3122ABL	House Dust Mite Extract, Biotinylated	Dermatophagoides pteronyssinus	D. pteronyssinus
na-3083A	House Dust Mite Extract	Dermatophagoides farinae	D. farinae
na-3122A	House Dust Mite Extract	Dermatophagoides pteronyssinus	D. pteronyssinus

Biological Functions of House Dust Mite Allergen Proteins

House dust mite allergen proteins play pivotal roles in the induction of allergic reactions. Der p 1, being a cysteine protease, is involved in the degradation of epithelial tight junctions, facilitating the penetration of other allergens. Der f 1, as a lipid-binding protein, interacts with lipids in the respiratory epithelium, enhancing the allergen's ability to elicit immune responses.

The biological functions of these allergen proteins are closely linked to their role in allergy. When inhaled or in contact with the skin, house dust mite allergens can activate the immune system, leading to the production of specific antibodies, such as IgE. This sensitization process sets the stage for subsequent allergic reactions upon re-exposure to the allergens. The molecular mechanisms underlying house dust mite allergies involve a complex interplay of immune cells, cytokines, and other mediators, resulting in the manifestation of symptoms like sneezing, itching, and respiratory distress.

Applications of House Dust Mite Allergen Proteins in Biomedicine

Diagnostic Development: House dust mite allergen proteins have found applications in diagnostic development, enabling healthcare professionals to identify and assess allergic sensitivities. Allergy tests, such as skin prick tests and specific IgE blood tests, often incorporate house dust mite allergens to pinpoint the exact triggers of allergic reactions. Accurate diagnosis facilitated by these allergen proteins allows for the development of personalized treatment plans tailored to the specific needs of individuals suffering from house dust mite allergies.
Vaccine Development: The immunogenic nature of house dust mite allergen proteins has spurred research into vaccine development. Vaccines designed to desensitize individuals to house dust mite allergens, known as allergen immunotherapy, aim to modify the immune response, ultimately reducing or eliminating allergic symptoms upon subsequent exposure. Through targeted administration of house dust mite allergen extracts or modified proteins, vaccine development holds promise in providing long-term relief for individuals with persistent house dust mite allergies.
Treatment Strategies: Biomedical researchers are investigating the development of therapeutic agents that can specifically target and neutralize the effects of house dust mite allergens. By blocking the interaction of these allergen proteins with the immune system, these treatments seek to mitigate allergic responses and provide effective relief to individuals suffering from house dust mite allergies.

Creative BioMart offers a comprehensive range of house dust mite allergen-related protein products, such as Der p 1 and Der p 2, are meticulously characterized and suitable for a wide range of research applications. Whether you're delving into the molecular mechanisms of allergies or developing diagnostic and therapeutic solutions, our products provide a solid foundation for your work. Contact us and explore our extensive catalog today to find the house dust mite allergen proteins that suit your specific requirements.