Pomegranates, hailed for their sweet and tart taste, harbor allergen proteins that can trigger allergic reactions in certain individuals. Pomegranate allergen proteins are primarily found in the seeds and juice sacs of the fruit. Pun g 1, Pun g 7, and Pun g 14 are key players in this group. These allergens belong to the molecular family of plant allergens, sharing characteristics with proteins from other fruits and vegetables that can elicit allergic reactions in susceptible individuals.
The structural intricacies of Pun g 1, Pun g 7, and Pun g 14 define their allergenic potential. Pun g 1, for instance, is a lipid transfer protein, known for its role in facilitating the transport of lipids between membranes. Pun g 7, identified as a pectinesterase, plays a role in modifying cell wall components. Pun g 14, classified as a profilin, contributes to cytoskeleton dynamics.
Classification of these proteins is an ongoing area of research. Pun g 1, as a member of the lipid transfer protein family, shares characteristics with allergens from other fruits, nuts, and seeds. Pun g 7, being a pectinesterase, aligns with allergens found in various fruits. Profilins, like Pun g 14, are widely distributed in plant tissues, contributing to their classification as pan-allergens.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3793P | Recombinant Pun g 1 | Punica granatum (Pomegranate) | E.coli or Yeast | His |
| ra-3794P | Recombinant Pun g 7 | Punica granatum (Pomegranate) | E.coli or Yeast | His |
| ra-3795P | Recombinant Pun g 14 | Punica granatum (Pomegranate) | E.coli or Yeast | His |
Pomegranate allergen proteins, including Pun g 1, Pun g 7, and Pun g 14, play crucial roles in the biological cascade leading to allergic reactions. Understanding these functions sheds light on the mechanisms underlying pomegranate allergies.
In allergic individuals, the immune system identifies pomegranate allergen proteins as foreign invaders, triggering an immune response. Pun g 1, Pun g 7, and Pun g 14, being allergenic, elicit the release of histamines and other inflammatory mediators. This immune response manifests as allergic symptoms, ranging from mild itching to severe anaphylaxis.
The molecular mechanisms leading to pomegranate allergy involve the interaction between these allergen proteins and the immune system. Pun g 1, for instance, may bind to specific receptors on immune cells, initiating a signaling cascade that culminates in the release of allergic mediators. Understanding these intricate interactions is essential for developing targeted therapies that modulate the immune response and alleviate allergic symptoms.
