Lilacs, with their vibrant colors and sweet fragrance, are beloved garden additions. However, for some individuals, the beauty of lilacs comes with an unexpected challenge – lilac allergens. Lilac allergens, primarily comprising proteins such as Syr v 1 and Syr v 3, fall under the umbrella of a specific molecular family. These proteins exhibit distinctive structural characteristics that contribute to their classification and potential impact on allergic reactions.
Lilac allergen proteins belong to the PR-10 family, a group of pathogenesis-related proteins commonly associated with plant defenses against pathogens. The PR-10 family is characterized by a conserved structure, often referred to as the Bet v 1-fold, which includes a central hydrophobic cavity. This structural feature is crucial for the allergenic properties of these proteins.
Syr v 1 and Syr v 3, two prominent lilac allergen proteins, share a common three-dimensional structure. They consist of a beta-sheet core surrounded by alpha-helices, creating a compact fold. This unique arrangement is a key factor in their allergenicity, influencing interactions with the human immune system.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3835P | Recombinant Syr v 1 | Syringa vulgaris (Lilac) | E.coli or Yeast | His |
| ra-3836P | Recombinant Syr v 3 | Syringa vulgaris (Lilac) | E.coli or Yeast | His |
Understanding the biological functions of lilac allergen proteins sheds light on their role in allergy and the molecular mechanisms behind allergic reactions. These proteins are not inherently harmful; instead, they play essential roles in the defense mechanisms of lilac plants.
The primary biological function of Syr v 1 and Syr v 3 is to protect lilacs from potential threats, including pathogens and pests. When the plant is exposed to stressors, these allergen proteins are produced as part of the defense response. However, in susceptible individuals, exposure to these proteins can lead to allergic reactions.
The allergic response to lilac allergen proteins involves the immune system's recognition of these proteins as foreign invaders. This recognition triggers the release of histamines and other inflammatory substances, leading to the classic symptoms of allergy, such as itching, sneezing, and nasal congestion. The molecular mechanisms underlying this immune response are complex and involve interactions between the lilac allergen proteins and specific immune cells.
Despite their role in allergy, lilac allergen proteins find applications in biomedicine, contributing to diagnostic development, vaccine research, and potential treatments.
Diagnostic development leverages the allergenic properties of Syr v 1 and Syr v 3. These proteins are utilized in allergy testing to identify individuals with lilac allergies accurately. Testing for specific allergens helps clinicians tailor treatment plans and avoid allergen exposure, enhancing patient care.
Vaccine development is another area where lilac allergen proteins show promise. Researchers explore the potential of using these proteins to develop vaccines that can desensitize individuals with lilac allergies. By exposing the immune system to controlled amounts of the allergen, vaccines aim to induce tolerance and reduce allergic reactions.
In the realm of treatment, understanding the molecular interactions between lilac allergen proteins and the immune system opens avenues for targeted therapies. Researchers investigate ways to modulate the immune response to prevent excessive reactions, providing potential relief for individuals with severe lilac allergies.
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