What is Rye Allergen

Rye allergens constitute a group of proteins present in rye grains that have the potential to induce allergic responses in susceptible individuals. These allergens are diverse, with distinct molecular characteristics, and are classified into different families based on their structures.

Rye Allergen Proteins: Composition and Classification

Rye allergen proteins encompass a variety of components, with Sec c 1, Sec c 5, Sec c 20, and Sec c 38 being notable examples. These proteins belong to the Secale cereal family, a molecular family specific to rye. Each of these proteins has a unique amino acid sequence, contributing to their allergenic properties.

Structurally, Sec c 1, Sec c 5, Sec c 20, and Sec c 38 exhibit variations that define their allergenicity. Sec c 1, for instance, is classified as a profilin protein, while Sec c 5 is a gliadin, Sec c 20 is a serpin, and Sec c 38 is a non-specific lipid-transfer protein. Understanding these structural nuances is crucial for both identification and classification of these allergen proteins.

Our Featured Rye Allergens

Cat.No.	Product Name	Species	Source	Tag
ra-3464P	Recombinant Sec c 1	Secale cereale (Rye)	E.coli or Yeast	His
ra-3465P	Recombinant Sec c 5	Secale cereale (Rye)	E.coli or Yeast	His
ra-3466P	Recombinant Sec c 20	Secale cereale (Rye)	E.coli or Yeast	His
ra-3467P	Recombinant Sec c 38	Secale cereale (Rye)	E.coli or Yeast	His

Rye Allergen Biological Functions and Allergic Responses

Rye allergen proteins, including Sec c 1, Sec c 5, Sec c 20, and Sec c 38, exert their influence through various biological functions, ultimately contributing to allergic reactions in sensitive individuals.

The primary biological function of these specific rye allergen proteins is their ability to trigger allergic responses. When consumed, they interact with the immune system, leading to the production of Immunoglobulin E (IgE) antibodies. The binding of IgE to these allergen proteins initiates a cascade of events, resulting in the release of histamines and other mediators, which manifest as allergy symptoms.

The molecular mechanisms behind rye allergies involve the recognition of specific epitopes on the surface of allergen proteins by the immune system. This recognition leads to the activation of immune cells and the subsequent release of inflammatory mediators, causing allergic symptoms. Sec c 1, Sec c 5, Sec c 20, and Sec c 38 each contribute uniquely to this cascade, further complicating the allergic response.

Applications of Rye Allergen Proteins in Biomedicine

Diagnostic Development: Sec c 1, Sec c 5, Sec c 20, and Sec c 38 are instrumental in the development of diagnostic tools for rye allergies. Immunoassays, such as ELISA, utilize these specific allergen proteins as antigens to detect the presence of allergen-specific IgE antibodies in patient samples. This aids in accurate and efficient diagnosis of rye allergies.
Vaccine Development: Research into the development of vaccines for rye allergies involves targeting specific allergen proteins like Sec c 1, Sec c 5, Sec c 20, and Sec c 38. Allergen-specific immunotherapy aims to desensitize individuals by exposing them to controlled doses of these proteins, gradually reducing their allergic responses over time.
Treatment Potential: Understanding the unique characteristics of Sec c 1, Sec c 5, Sec c 20, and Sec c 38 opens avenues for targeted treatments. Novel therapeutic approaches, including the use of monoclonal antibodies and small molecule inhibitors, aim to disrupt the molecular interactions that lead to allergic responses, offering potential relief for individuals with rye allergies.