Dog allergen proteins assume a pivotal role in initiating allergic responses among individuals with sensitivities to these proteins. These allergen proteins, officially designated as Canis lupus familiaris allergen proteins, form a diverse category primarily categorized within the expansive lipocalin protein family. In the ensuing sections, we will embark on a comprehensive exploration of dog allergen proteins, unraveling their intricate structural characteristics and elucidating their specific classification within the broader realm of allergenic agents.
Dog allergen proteins encompass a wide array of molecules that trigger allergic responses in susceptible individuals. One of the most prominent allergens is Can f 1, which stands for Canis familiaris allergen 1. It belongs to the lipocalin family, characterized by their barrel-shaped structures with a hydrophobic binding pocket. Lipocalins have a remarkable ability to bind and transport small hydrophobic molecules, which, in the context of dog allergens, often includes proteins associated with allergies.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3310A | Recombinant Can f 1 | Dog | E.coli | His |
| ra-3310AB | Recombinant Can f 1, Biotin Labeled | Dog | E.coli | His |
| ra-3311A | Recombinant Can f 2 | Dog | E.coli | His |
| ra-3311AB | Recombinant Can f 2, Biotin Labeled | Dog | E.coli | His |
| na-3312A | Native Dog Can f 3 Allergen | Canis familiaris (C. lupus familiaris) (Domestic dog) | Dog Serum | |
| ra-3312A | Recombinant Can f 3 | Canis familiaris (C. lupus familiaris) (Domestic dog) | Yeast | His |
| ra-3312AB | Recombinant Can f 3, Biotin Labeled | Canis familiaris (C. lupus familiaris) (Domestic dog) | Yeast | His |
| na-3312AB | Native Dog Can f 3 Allergen, Biotin Labeled | Canis familiaris (C. lupus familiaris) (Domestic dog) | Dog Serum | |
| ra-3313A | Recombinant Can f 4 | Canis familiaris (C. lupus familiaris) (Domestic dog) | E.coli | His |
| ra-3314A | Recombinant Can f 5 | Canis familiaris (C. lupus familiaris) (Domestic dog) | Yeast | His |
| ra-3314AB | Recombinant Can f 5, Biotin Labeled | Canis familiaris (C. lupus familiaris) (Domestic dog) | Yeast | His |
| ra-3318A | Recombinant Can f 6 | Canis familiaris (C. lupus familiaris) (Domestic dog) | E.coli or Yeast | His |
| ra-3315A | Recombinant Can f 7 | Canis familiaris (C. lupus familiaris) (Domestic dog) | Yeast | His |
| ra-3315AB | Recombinant Can f 7, Biotin Labeled | Canis familiaris (C. lupus familiaris) (Domestic dog) | Yeast | His |
| ra-3316A | Recombinant Can f 8 | Canis familiaris (C. lupus familiaris) (Domestic dog) | E.coli or Yeast | His |
Dog allergen proteins are not inherently harmful, but they can incite allergic reactions in some people. These proteins usually originate from a dog's skin, saliva, urine, and dander. When these allergen proteins come into contact with a susceptible individual, the immune system may perceive them as foreign invaders, leading to the production of IgE antibodies.
The molecular mechanism behind dog allergen-induced allergies involves the binding of IgE antibodies to mast cells and basophils, immune cells that are abundant in tissues like the skin and respiratory tract. Upon subsequent exposure to the allergen, the bound IgE antibodies trigger these cells to release histamines and other inflammatory mediators. This cascade of events leads to classic allergy symptoms such as itching, sneezing, and wheezing.
Dog allergen proteins have found crucial applications in the field of allergy diagnosis and treatment. Diagnostic tools like skin prick tests and blood tests use specific allergen proteins, including Can f 1, to identify allergies in individuals. These tests help doctors pinpoint the exact allergen causing the reaction, allowing for tailored treatment plans.
In the realm of allergy treatment and prevention, allergen immunotherapy (AIT) has emerged as a promising approach. AIT, often referred to as allergy shots, involves exposing allergic individuals to small, controlled doses of dog allergen proteins over an extended period. This exposure helps the immune system become desensitized to the allergen, reducing the severity of allergic reactions over time.
Researchers are also exploring the development of vaccines that target dog allergen proteins. These vaccines aim to induce immune tolerance to the allergen, much like AIT, but through a different mechanism. By stimulating the production of regulatory T cells and suppressing the IgE-mediated immune response, these vaccines hold the potential to offer long-term relief to dog allergy sufferers.
Creative BioMart offers a comprehensive range of dog allergen-related protein products to meet your research needs. Our high-quality proteins are meticulously produced and rigorously tested, ensuring reliability and accuracy in your experiments. Whether you are studying the structural characteristics, biological functions, or developing diagnostic tools and therapies, our dog allergen proteins are the ideal choice for advancing your research. Contact us and explore our diverse catalog and discover the excellence in dog allergen research with us.
