Frogs, those charming amphibious creatures that often inhabit our wetlands and gardens, may seem innocuous at first glance. However, for individuals with frog allergies, these seemingly harmless animals can trigger a range of allergic reactions. These allergic responses are primarily caused by specific proteins found in frogs, aptly known as frog allergen proteins. These proteins, denoted by their abbreviation rana, encompass a diverse array of molecules. Rana allergen proteins belong to the allergen molecular family and exhibit unique structural characteristics that can vary between different frog species, posing distinct challenges in the realm of allergy diagnosis and treatment.
Rana allergen proteins are notorious for their variability, which stems from the vast diversity of frog species. Some common frog allergens include rana catesbeiana, rana esculenta, and rana grylio, each with its own set of allergenic proteins. These allergens belong to the molecular family of amphibian proteins, characterized by their relatively small size, typically ranging from 12 to 30 kilodaltons. The structural diversity among rana allergens arises from variations in amino acid sequences, post-translational modifications, and protein folding patterns, making them challenging to study comprehensively.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3385A | Recombinant Ran e 1 | Rana esculenta (Pelophylax esculentus) (Edible frog) | E.coli or Yeast | His |
| ra-3386A | Recombinant Ran e 2 | Rana esculenta (Pelophylax esculentus) (Edible frog) | E.coli or Yeast | His |
The biological functions of frog allergen proteins extend beyond their role in amphibian physiology. These proteins trigger allergic reactions by binding to specific immunoglobulin E (IgE) antibodies in individuals with frog allergies. When a susceptible individual is exposed to frog allergen proteins, their immune system perceives these proteins as threats. In response, IgE antibodies are produced, and upon subsequent exposure, they bind to the allergen proteins, initiating an allergic cascade.
The molecular mechanisms underpinning frog allergies are intricate. Upon binding, IgE antibodies activate immune cells called mast cells, leading to the release of inflammatory mediators such as histamine. This release results in the classic allergic symptoms, including skin rashes, itching, sneezing, and even life-threatening anaphylactic reactions in severe cases. The precise mechanisms by which frog allergens induce IgE production and subsequent mast cell activation are still areas of ongoing research, but understanding these processes is crucial for effective allergy management.
The identification and characterization of frog allergen proteins have paved the way for advancements in allergy diagnosis, vaccine development, and treatment.
Creative BioMart offers a comprehensive range of frog allergen-related protein products, catering to your research needs. Our high-quality proteins are meticulously produced and rigorously tested to ensure accuracy and reliability in your experiments. Contact us and explore our comprehensive selection of frog allergen proteins and experience the difference of working with us today.
