What is Wormwood Allergen

Wormwood, scientifically known as Artemisia, is a genus of plants that encompasses various species, some of which are notorious for triggering allergic reactions in susceptible individuals. This article delves into the world of Wormwood allergen proteins, exploring their molecular intricacies, biological functions, and potential applications in biomedicine.

Wormwood Allergen Proteins: Composition and Classification

Wormwood allergens primarily include proteins belonging to the molecular family of profilins, a group of small, highly conserved proteins with crucial roles in cell regulation. Profilins are known for their involvement in actin polymerization, which is vital for cellular processes like cytoskeletal organization and intracellular transport.

Wormwood allergen proteins possess distinct structural characteristics that make them recognizable within the profilin family. Their three-dimensional structures consist of a central beta-sheet surrounded by alpha-helices, a configuration that facilitates their binding to actin and other cellular components. Classification within the allergen spectrum is attributed to the presence of specific amino acid sequences and epitopes that trigger immune responses in sensitive individuals.

Our Featured Wormwood Allergens

Cat.No.	Product Name	Species	Source	Tag
ra-3572P	Recombinant Art ab 1	Artemisia absinthium (Absinthe wormwood)	E.coli or Yeast	His
ra-3573P	Recombinant Art an 1	Artemisia annua (Sweet Wormwood)	E.coli or Yeast	His
ra-3574P	Recombinant Art an 1	Artemisia annua (Sweet Wormwood)	E.coli or Yeast	His
ra-3575P	Recombinant Art an 2	Artemisia annua (Sweet Wormwood)	E.coli or Yeast	His
ra-3576P	Recombinant Art an 3	Artemisia annua (Sweet Wormwood)	E.coli or Yeast	His
ra-3577P	Recombinant Art an 7	Artemisia annua (Sweet Wormwood)	E.coli or Yeast	His
ra-3578P	Recombinant Art ar 1	Artemisia argyi (Silvery wormwood)	E.coli or Yeast	His
ra-3579P	Recombinant Art ar 2	Artemisia argyi (Silvery wormwood)	E.coli or Yeast	His
ra-3580P	Recombinant Art ar 3	Artemisia argyi (Silvery wormwood)	E.coli or Yeast	His
ra-3581P	Recombinant Art c 1	Artemisia californica (California sagebrush)	E.coli or Yeast	His
ra-3582P	Recombinant Art f 1	Artemisia frigida (Desert sagebrush)	E.coli or Yeast	His
ra-3583P	Recombinant Art l 1	Artemisia ludoviciana (Silver wormwood)	E.coli or Yeast	His
ra-3584P	Recombinant Art t 1	Artemisia tridentata (Common sagebrush)	E.coli or Yeast	His
ra-3585P	Recombinant Art v 1	Mugwort, wormwood	E.coli	His
ra-3585PB	Recombinant Art v 1, Biotin Labeled	Mugwort, wormwood	E.coli	His
ra-3585PM	Recombinant Art v 1	Mugwort, wormwood	HEK293 Cells	His
ra-3586P	Recombinant Art v 2	Artemisia vulgaris (Mugwort, wormwood)	E.coli or Yeast	His
ra-3587P	Recombinant Art v 3	Mugwort, wormwood	E.coli	His
ra-3587PB	Recombinant Art v 3, Biotin Labeled	Mugwort, wormwood	E.coli	His
ra-3588P	Recombinant Art v 4	Artemisia vulgaris (Mugwort, wormwood)	E.coli	His
ra-3588P-1	Recombinant Art v 4.01	Mugwort, wormwood	E.coli	His
ra-3588P-1B	Recombinant Art v 4.01, Biotin Labeled	Mugwort, wormwood	E.coli	His
ra-3589P	Recombinant Art v 5	Artemisia vulgaris (Mugwort, wormwood)	E.coli or Yeast	His
ra-3590P	Recombinant Art v 6	Artemisia vulgaris (Mugwort, wormwood)	E.coli or Yeast	His
ra-3978P	Recombinant Art ca 1	Artemisia capillaris (Wormwood)	E.coli or Yeast	His
ra-3979P	Recombinant Art ca 2	Artemisia capillaris (Wormwood)	E.coli or Yeast	His
ra-3980P	Recombinant Art ca 3	Artemisia capillaris (Wormwood)	E.coli or Yeast	His
ra-3981P	Recombinant Art gm 1	Artemisia gmelinii (Russian wormwood)	E.coli or Yeast	His
ra-3982P	Recombinant Art gm 2	Artemisia gmelinii (Russian wormwood)	E.coli or Yeast	His
ra-3983P	Recombinant Art gm 3	Artemisia gmelinii (Russian wormwood)	E.coli or Yeast	His
ra-3987P	Recombinant Art si 1	Artemisia sieversiana (Sieversian wormwood)	E.coli or Yeast	His
ra-3988P	Recombinant Art si 2	Artemisia sieversiana (Sieversian wormwood)	E.coli or Yeast	His
ra-3989P	Recombinant Art si 3	Artemisia sieversiana (Sieversian wormwood)	E.coli or Yeast	His

Wormwood Allergen Biological Functions and Allergic Responses

Wormwood allergen proteins play a pivotal role in the development of allergic reactions, especially in individuals with a predisposition to pollen allergies. These proteins act as potent allergens when inhaled or come into contact with mucosal surfaces, leading to the activation of the immune system. The allergic response involves the release of histamines and other inflammatory mediators, resulting in symptoms such as sneezing, itching, and nasal congestion.

Wormwood allergens are notorious for causing allergic rhinitis, commonly known as hay fever, during the pollen season. Individuals sensitive to Wormwood allergens may experience symptoms ranging from mild irritation to severe respiratory distress. The molecular mechanisms underlying Wormwood allergy involve the recognition of allergen proteins by the immune system, leading to the production of specific antibodies, primarily IgE. Upon subsequent exposure, these antibodies trigger the release of histamines, initiating the allergic cascade.

The interaction between Wormwood allergen proteins and the immune system occurs through a complex process known as sensitization. During the initial exposure, the immune system recognizes the allergen as a foreign invader and produces specific antibodies against it. Upon subsequent encounters, these antibodies bind to the allergen, triggering the release of inflammatory substances, causing the characteristic allergic symptoms. Understanding these molecular mechanisms is crucial for developing targeted therapies to alleviate allergic reactions.

Applications of Wormwood Allergen Proteins in Biomedicine

Diagnostic Development: Wormwood allergen proteins serve as valuable tools in the development of diagnostic tests for identifying individuals with Wormwood allergies. Immunoassays, such as enzyme-linked immunosorbent assays (ELISA), utilize these proteins as antigens to detect specific IgE antibodies in patient serum. Accurate diagnosis is essential for effective management and personalized treatment strategies for allergic individuals.
Vaccine Development: Efforts are underway to harness the immunogenic properties of Wormwood allergen proteins for vaccine development. Allergen-specific immunotherapy (AIT) aims to desensitize individuals by exposing them to gradually increasing doses of the allergen. This approach modifies the immune response, reducing the severity of allergic reactions upon subsequent exposures. Wormwood allergen proteins, when incorporated into AIT formulations, hold promise for developing targeted vaccines against Wormwood allergies.
Treatment Strategies: Understanding the molecular basis of Wormwood allergies opens avenues for the development of targeted treatment strategies. Innovative therapeutic approaches, such as monoclonal antibodies and small molecule inhibitors, are being explored to mitigate the allergic response triggered by Wormwood allergen proteins. These advancements offer hope for more effective and personalized treatment options, providing relief to individuals suffering from Wormwood allergies.