Sesame, a commonly used ingredient in various cuisines, has recently gained attention due to its allergenic potential. Sesame allergen proteins, a subset of compounds found in sesame seeds, can trigger allergic reactions in sensitive individuals. Sesame allergen proteins primarily include several families of proteins, with the major allergens belonging to the cupin superfamily. Cupins are known for their diverse functions, and within sesame seeds, specific proteins like Ses i 1, Ses i 2, and Ses i 3 are recognized as major allergens. These proteins exhibit distinct structural characteristics, featuring conserved cupin motifs, which play a crucial role in their allergenicity.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3813P | Recombinant Ses i 1 | Sesamum indicum (Sesame) | E.coli | His |
| ra-3814P | Recombinant Ses i 2 | Sesamum indicum (Sesame) | E.coli or Yeast | His |
| ra-3815P | Recombinant Ses i 3 | Sesamum indicum (Sesame) | E.coli or Yeast | His |
| ra-3816P | Recombinant Ses i 4 | Sesamum indicum (Sesame) | E.coli or Yeast | His |
| ra-3817P | Recombinant Ses i 5 | Sesamum indicum (Sesame) | E.coli or Yeast | His |
| ra-3818P | Recombinant Ses i 6 | Sesamum indicum (Sesame) | E.coli or Yeast | His |
| ra-3819P | Recombinant Ses i 7 | Sesamum indicum (Sesame) | E.coli or Yeast | His |
Despite being primarily known as allergens, sesame allergen proteins also serve essential biological functions within the sesame seed. Ses i 1, for instance, is a 2S albumin storage protein with the main role of providing a nutrient reserve for the developing sesame plant. Ses i 2, belonging to the cupin superfamily, is involved in various physiological processes crucial for seed development. Ses i 3, another prominent allergen, shares homology with oleosins, which are vital for lipid storage within seeds.
Allergic reactions to sesame allergen proteins can range from mild symptoms, such as itching and swelling, to severe anaphylaxis, posing a significant health concern. The molecular mechanisms underlying sesame allergy involve the immune system's misidentification of sesame proteins as harmful invaders. The immune response triggers the release of histamines and other inflammatory mediators, leading to allergic symptoms.
The sensitization process begins when individuals with a genetic predisposition encounter sesame allergen proteins. Upon exposure, the immune system recognizes these proteins as foreign entities and produces specific immunoglobulin E (IgE) antibodies. In subsequent encounters, the IgE antibodies bind to mast cells and basophils, triggering the release of histamines and other inflammatory substances. This cascade of events results in the manifestation of allergic symptoms, ranging from mild to severe.
