Fly allergen proteins constitute a family of complex molecules that wield a considerable influence in triggering allergic reactions when individuals come into contact with flies. Within the realm of allergenic substances, these proteins prominently align themselves with the molecular family of insect aeroallergens. They serve as the chief instigators of allergic responses in those individuals whose immune systems are sensitive to their presence, whether through inhalation or direct contact with flies. To gain a more profound understanding of the intricate world of fly allergen proteins, it is imperative to embark on a journey that unravels their intricate structural compositions, their taxonomic categorizations, and their nomenclature.
Fly allergen proteins exhibit diverse structural characteristics, often comprising complex, three-dimensional arrangements of amino acids. These proteins can be categorized into distinct families based on their sequence homology and allergenic properties. Among the most well-known fly allergen proteins are Tab y 1, Tab y 2, and Tab y 5, derived from the Horsefly (Tabanus yao), as well as Glo m 5, obtained from the Savannah tsetse fly (Glossina morsitans). Tab y 1, known as the Horsefly tropomyosin, is a major allergen responsible for provoking allergic reactions in individuals sensitized to fly allergens. Another prominent allergen, Tab y 5, belongs to the odorant-binding protein family. Similarly, Glo m 5 from the Savannah tsetse fly has its unique characteristics. The classification of fly allergen proteins is crucial for understanding their role in allergies and developing effective diagnostic tools and treatments.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3258A | Recombinant Tab y 1 | Tabanus yao (Horsefly) | E.coli or Yeast | His |
| ra-3259A | Recombinant Tab y 2 | Tabanus yao (Horsefly) | E.coli or Yeast | His |
| ra-3260A | Recombinant Tab y 5 | Tabanus yao (Horsefly) | E.coli or Yeast | His |
| ra-3165A | Recombinant Glo m 5 | Glossina morsitans (Savannah tsetse fly) | E.coli or Yeast | His |
Fly allergen proteins serve specific biological functions within the fly's physiology, but it's their inadvertent interaction with the human immune system that sparks allergic responses. These proteins often act as carriers for volatile chemicals, aiding in the fly's sensory perception and navigation. However, when inhaled or encountered by humans, they can trigger an immune response. The molecular mechanisms underlying fly allergy involve the activation of the immune system's IgE antibodies, which recognize and bind to specific epitopes on the allergen proteins. This binding initiates a cascade of immune reactions, resulting in the release of histamines and other inflammatory mediators, leading to allergic symptoms such as sneezing, itching, and nasal congestion.
The study of fly allergen proteins has significant implications in the development of diagnostic tools and treatments for fly allergies. Understanding the specific allergenic proteins involved enables the creation of allergen-specific diagnostic tests, aiding in the identification of individuals sensitized to fly allergens. These tests can help healthcare professionals tailor allergy management strategies and avoidance measures for affected patients.
Moreover, the knowledge of fly allergen proteins is instrumental in vaccine development. Researchers are exploring the possibility of using these allergen proteins to formulate allergy vaccines, known as allergen immunotherapy. These vaccines aim to desensitize individuals to fly allergens by gradually exposing them to increasing doses of the allergen proteins. This process helps modulate the immune response, reducing allergic reactions and improving the quality of life for those afflicted by fly allergies.
At Creative BioMart, we are your trusted source for high-quality fly allergen-related protein products. Our extensive catalog boasts a wide range of allergen proteins, including those from flies like Musca domestica and Tabanus yao (Horsefly), as well as Glossina morsitans (Savannah tsetse fly). Whether you are conducting research into fly allergies, diagnostics development, or vaccine formulation, our meticulously purified and characterized allergen proteins are the key to unlocking insights and advancing your projects. Contact us and explore our comprehensive selection of fly allergen proteins and experience the difference of working with us today.
