Saffron Crocus, known for its vibrant crimson stigma and culinary significance, harbors allergen proteins that have piqued the interest of researchers in recent years. Two major allergen proteins, namely Cro s 1 and Cro s 2, play a pivotal role in triggering allergic reactions.
Saffron Crocus allergen proteins are components found in the saffron spice derived from the Crocus sativus plant. Among the various proteins present, Cro s 1 and Cro s 2 have been identified as the primary allergens responsible for allergic reactions in susceptible individuals. These allergens belong to the pathogenesis-related protein (PR-10) family, a group of proteins associated with plant defense mechanisms.
Cro s 1 and Cro s 2 share common structural features typical of PR-10 proteins. PR-10 proteins are characterized by a conserved three-dimensional fold, forming a barrel-like structure with a hydrophobic cavity. Cro s 1 and Cro s 2 exhibit these characteristic features, facilitating their classification within the PR-10 family.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3410P | Recombinant Cro s 1 | Crocus sativus (Saffron crocus) | E.coli or Yeast | His |
| ra-3411P | Recombinant Cro s 2 | Crocus sativus (Saffron crocus) | E.coli or Yeast | His |
The biological functions of Saffron Crocus allergen proteins are intertwined with the plant's defense mechanisms. PR-10 proteins, including Cro s 1 and Cro s 2, play a role in protecting plants against various environmental stressors, such as pathogens and abiotic stresses. However, in individuals with allergies, these proteins can trigger immune responses, leading to allergic reactions.
Saffron Crocus allergens, particularly Cro s 1 and Cro s 2, can induce allergic reactions in susceptible individuals upon exposure. Allergy to saffron spice is characterized by symptoms such as itching, swelling, hives, and in severe cases, anaphylaxis. The molecular mechanisms underlying saffron allergy involve the recognition of these allergen proteins by the immune system, leading to the release of histamines and other mediators that cause allergic symptoms.
The molecular mechanisms driving saffron allergy are complex and involve the interaction between Saffron Crocus allergen proteins and the immune system. Upon exposure to saffron, individuals with allergies produce specific immunoglobulin E (IgE) antibodies that recognize and bind to Cro s 1 and Cro s 2. This binding triggers the release of histamines and other inflammatory molecules, resulting in the manifestation of allergic symptoms.
