Chicken is a widely consumed poultry product around the world, appreciated for its versatility in culinary applications. However, for some individuals, chicken can be more than just a delicious meal—it can be a source of allergies. Chicken allergen proteins are the key culprits responsible for triggering allergic reactions in susceptible individuals. In this article, we will delve into the details of chicken allergen proteins, exploring their composition, biological functions, and their significance in diagnostic development, vaccine development, and treatment.
Chicken allergen proteins primarily include Gal d 1, Gal d 2, and Gal d 3, among others. Gal d 1, also known as ovomucoid, is a member of the serpin superfamily and is known for its heat stability, making it resistant to cooking. Gal d 2, or ovalbumin, is a prominent allergen in chicken eggs, but it can also be present in chicken meat due to cross-contamination during processing. Gal d 3, or lysozyme, is another chicken allergen, which belongs to the glycoside hydrolase family. These allergens exhibit structural characteristics that enable them to provoke immune responses in sensitive individuals, typically involving IgE antibodies.
| Cat.No. | Product Name | Species | Source | Tag |
| na-3348A | Native Chicken Gal d 1 Allergen | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| ra-3348A | Recombinant Gal d 1 | Gallus domesticus (G. gallus) (Chicken) | Yeast | His |
| ra-3348AB | Recombinant Gal d 1, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Yeast | His |
| na-3348AB | Native Chicken Gal d 1 Allergen, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| ra-3348AM | Recombinant Gal d 1 | Gallus domesticus (G. gallus) (Chicken) | HEK293 Cells | His |
| ra-3357A | Recombinant Gal d 10 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| na-3349A | Native Chicken Gal d 2 Allergen | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| ra-3349A | Recombinant Gal d 2 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| na-3349AB | Native Chicken Gal d 2 Allergen, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| na-3350A | Native Chicken Gal d 3 Allergen | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| ra-3350A | Recombinant Gal d 3 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| na-3350AB | Native Chicken Gal d 3 Allergen, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| na-3351A | Native Chicken Gal d 4 Allergen | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| ra-3351A | Recombinant Gal d 4 | Gallus domesticus (G. gallus) (Chicken) | E.coli | N/A |
| ra-3351AB | Recombinant Gal d 4, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | E.coli | N/A |
| na-3351AB | Native Chicken Gal d 4 Allergen, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg White | |
| na-3352A | Native Chicken Gal d 5 Allergen | Gallus domesticus (G. gallus) (Chicken) | Chicken Serum | |
| ra-3352A | Recombinant Gal d 5 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| na-3352AB | Native Chicken Gal d 5 Allergen, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Chicken Serum | |
| ra-3353A | Recombinant Gal d 6 | Gallus domesticus (G. gallus) (Chicken) | E.coli | His |
| ra-3353AB | Recombinant Gal d 6, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | E.coli | His |
| ra-3354A | Recombinant Gal d 7 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| ra-3355A | Recombinant Gal d 8 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| ra-3356A | Recombinant Gal d 9 | Gallus domesticus (G. gallus) (Chicken) | E.coli or Yeast | His |
| na-3357A | Native Chicken Yolk Immunoglobulin Allergen | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg Yolk | |
| na-3357AB | Native Chicken Yolk Immunoglobulin Allergen, Biotin Labeled | Gallus domesticus (G. gallus) (Chicken) | Chicken Egg Yolk |
Chicken allergen proteins serve essential functions within the bird's biology. Ovomucoid (Gal d 1), for instance, acts as a protease inhibitor in the egg white, protecting the developing embryo from predation by inhibiting digestive enzymes. Ovalbumin (Gal d 2) is the major protein in egg white, providing necessary nutrients for the embryo's growth. Lysozyme (Gal d 3) functions as an antimicrobial enzyme, protecting the egg against microbial contamination.
However, for individuals with chicken allergies, exposure to these proteins can trigger allergic reactions. Upon ingestion or contact, chicken allergen proteins can bind to specific IgE antibodies, leading to the activation of immune cells such as mast cells and basophils. This immune response can result in symptoms ranging from mild itching and hives to severe anaphylaxis, a life-threatening condition characterized by difficulty breathing and a drop in blood pressure. The molecular mechanisms underlying chicken protein allergies are complex and involve the release of inflammatory mediators such as histamine.
Understanding chicken allergen proteins is crucial for developing effective diagnostic tools, vaccines, and treatments for individuals with chicken allergies.
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