Papaya, a delectable tropical fruit, harbors allergen proteins that have drawn scientific interest, notably Cari p 1 and Cari p 2. These allergen proteins play a pivotal role in triggering allergic reactions in certain individuals. Let's delve into the intricacies of papaya allergen proteins, exploring their composition, molecular family, structural characteristics, and classification.
Papaya allergen proteins predominantly consist of Cari p 1 and Cari p 2, both of which belong to the papain-like cysteine protease family. Cari p 1, a major allergen in papaya, exhibits enzymatic activity and is responsible for the fruit's characteristic taste and texture. Cari p 2, another crucial allergen, shares similarities with Cari p 1 but possesses unique structural features, contributing to the allergenicity of papaya.
Cari p 1 and Cari p 2 display distinctive structural characteristics. Cari p 1, as a cysteine protease, showcases a three-dimensional arrangement comprising a catalytic triad involving cysteine, histidine, and asparagine. This unique structure allows Cari p 1 to catalyze proteolytic reactions, contributing to the ripening of papaya. On the other hand, Cari p 2, while sharing the overall structural framework, exhibits sequence variations that influence its specific enzymatic properties.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3614P | Recombinant Cari p 1 | Carica papaya (Papaya) | E.coli or Yeast | His |
| ra-3615P | Recombinant Cari p 2 | Carica papaya (Papaya) | E.coli or Yeast | His |
The biological functions of papaya allergen proteins extend beyond their role in fruit ripening. Understanding the intricate mechanisms behind the functions of Cari p 1 and Cari p 2 is crucial in comprehending the allergic responses they elicit in susceptible individuals.
Papaya allergy, often attributed to Cari p 1 and Cari p 2, manifests as an immune response to these allergen proteins. Individuals sensitized to papaya allergens may experience a spectrum of allergic symptoms, ranging from mild skin reactions to severe anaphylaxis. The allergic reactions are initiated when the immune system recognizes specific epitopes on Cari p 1 and Cari p 2, leading to the production of immunoglobulin E (IgE) antibodies.
The molecular mechanisms underlying papaya allergy involve the binding of IgE antibodies to mast cells and basophils. Upon subsequent exposure to papaya allergens, these cells release histamine and other inflammatory mediators, triggering allergic symptoms. The unique enzymatic activity of Cari p 1 and Cari p 2 contributes to their allergenic potential, making them key players in the induction of papaya allergy.
