Cherry allergens, the often-overlooked triggers of allergic reactions, play a crucial role in understanding and managing allergies related to cherries. These allergens primarily include proteins that belong to the pathogenesis-related (PR) family. Within this molecular family, the cherry allergen proteins exhibit unique structural characteristics that distinguish them from other allergens.
Cherry allergen proteins are classified based on their molecular structures and functionalities. The major allergenic proteins in cherries are classified into different groups, with Pru av 1 and Pru av 3 being the most prominent. Pru av 1 is categorized as a Bet v 1 homolog, sharing structural similarities with birch pollen allergens. On the other hand, Pru av 3 belongs to the lipid transfer protein (LTP) family. Understanding these structural nuances is essential for comprehending the allergenic potential of cherries.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3774P | Recombinant Pru av 1 | Prunus avium (Sweet cherry) | E.coli or Yeast | His |
| ra-3775P | Recombinant Pru av 2 | Prunus avium (Sweet cherry) | E.coli or Yeast | His |
| ra-3776P | Recombinant Pru av 3 | Prunus avium (Sweet cherry) | E.coli or Yeast | His |
| ra-3777P | Recombinant Pru av 4 | Prunus avium (Sweet cherry) | E.coli or Yeast | His |
| ra-3778P | Recombinant Pru av 7 | Prunus avium (Sweet cherry) | E.coli or Yeast | His |
Delving into the biological functions of cherry allergen proteins uncovers their pivotal role in allergic reactions. These proteins trigger immune responses, leading to allergic symptoms upon exposure. The allergic reactions associated with cherry allergens are diverse and can range from mild symptoms like itching and hives to severe anaphylactic responses.
Cherry allergen proteins, when introduced into the body, stimulate the immune system to produce specific antibodies, primarily immunoglobulin E (IgE). These antibodies recognize and bind to the allergen, initiating the release of histamines and other chemicals. This cascade of events results in the manifestation of allergic symptoms. The severity of the allergic reaction is often determined by the individual's sensitivity and the amount of cherry allergen exposure.
The molecular mechanisms underlying cherry allergies involve intricate interactions between the allergen proteins and the immune system. The three-step process – sensitization, activation, and effector phase – elucidates how the immune system responds to cherry allergens. Sensitization occurs during the initial exposure, where the immune system recognizes and produces specific IgE antibodies. Upon subsequent exposures, these antibodies trigger the activation of immune cells, leading to the release of inflammatory mediators and the manifestation of allergy symptoms.
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