Orange allergen proteins constitute a diverse group of molecules found in oranges that can trigger allergic reactions in susceptible individuals. These proteins primarily belong to the PR-10 family, a class of pathogenesis-related proteins. PR-10 proteins are known for their involvement in plant defense mechanisms against pathogens, making them an essential component of the plant's immune system.
The structural characteristics of orange allergen proteins play a pivotal role in their allergenic potential. PR-10 proteins typically adopt a compact, globular structure, stabilized by multiple disulfide bridges. This structure allows them to resist degradation in the gastrointestinal tract, increasing their allergenicity.
Orange allergen proteins are further classified based on their sequence homology and structural features. Notable members of this allergen family include Cit s 1 and Cit s 3, which have been identified as major allergens in oranges. These proteins exhibit distinct IgE-binding epitopes, contributing to their allergenic properties.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3632P | Recombinant Cit s 1 | Citrus sinensis (Sweet orange) | E.coli or Yeast | His |
| ra-3633P | Recombinant Cit s 2 | Citrus sinensis (Sweet orange) | E.coli or Yeast | His |
| ra-3634P | Recombinant Cit s 3 | Citrus sinensis (Sweet orange) | E.coli or Yeast | His |
| ra-3635P | Recombinant Cit s 7 | Citrus sinensis (Sweet orange) | E.coli or Yeast | His |
While orange allergen proteins play a crucial role in the plant's defense mechanisms, their presence in fruits can lead to allergic reactions in susceptible individuals. The biological functions of these proteins extend beyond plant defense to their involvement in allergy-related processes.
The role of orange allergens in allergy is primarily attributed to their ability to stimulate the immune system in predisposed individuals. Upon ingestion or contact with the allergen, the immune system recognizes these proteins as foreign invaders, triggering an allergic response. The molecular mechanisms underlying orange allergen-induced allergy involve the activation of mast cells and the release of histamine, leading to the characteristic symptoms of allergic reactions.
Understanding the specific IgE-binding epitopes on orange allergen proteins provides valuable insights into the molecular interactions that initiate and perpetuate allergic responses. This knowledge is essential for developing targeted therapeutic interventions to alleviate allergic symptoms and improve the quality of life for affected individuals.
