Cat flea allergen proteins may often escape our attention, yet their presence can significantly influence the lives of both feline companions and their human counterparts. These proteins are part of the allergen molecular family and are responsible for triggering allergic reactions in individuals who are susceptible to their effects. In this article, we embark on a journey into the realm of cat flea allergen proteins, delving deep into their composition, deciphering their functions, and unveiling their pivotal role in advancing diagnostic techniques, vaccine research, and treatment methods.
Cat flea allergen proteins primarily include Cte f 2, Cte f 3, Cul q 2, and Cte f 1 allergenic proteins. Cte f 1, in particular, is a major allergen produced primarily in a cat's sebaceous glands and saliva. Cte f 2 and Cte f 3, on the other hand, are found in the skin and fur of cats, while Cul q 2 is an allergen associated with the saliva of the cat flea. These allergens belong to the cysteine protease family. Structurally, they are characterized by their enzyme-like properties, featuring an active site containing a catalytic triad. This structural feature plays a pivotal role in their allergenicity.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3090A | Recombinant Cte f 1 | Ctenocephalides felis (Cat flea) | E.coli | His |
| ra-3090AB1 | Recombinant Cte f 1, Biotin Labeled | Ctenocephalides felis (Cat flea) | E.coli | His-Sumo |
| ra-3090AB2 | Recombinant Cte f 1, Biotin Labeled | Ctenocephalides felis (Cat flea) | E.coli | His |
| ra-3079A | Recombinant Cte f 2 | Ctenocephalides felis (Cat flea) | E.coli or Yeast | His |
| ra-3081A | Recombinant Cte f 3 | Ctenocephalides felis (Cat flea) | E.coli or Yeast | His |
| ra-3082A | Recombinant Cul q 2 | Ctenocephalides felis (Cat flea) | E.coli or Yeast | His |
The biological functions of cat flea allergen proteins are somewhat paradoxical. For the feline host, these proteins serve as essential components of their grooming mechanism, aiding in the breakdown of keratin in their fur. However, for those allergic to these proteins, exposure can trigger a cascade of immune responses.
Allergic reactions occur when the immune system misidentifies harmless substances, such as cat flea allergen proteins, as threats. In response to exposure, the body produces immunoglobulin E (IgE) antibodies, specifically targeting these proteins. The next encounter with the allergen triggers mast cells to release histamines, leading to the classic allergic symptoms like sneezing, itching, and respiratory distress.
Cat flea allergen proteins have played a crucial role in the development of diagnostic tools for allergies. Specific IgE blood tests can measure the levels of IgE antibodies directed against these allergens in an individual's bloodstream. This helps identify if someone is allergic to cats, even if they have not had direct contact with a feline. Furthermore, skin prick tests, which involve exposing the skin to tiny amounts of allergen extracts, can pinpoint specific allergens responsible for allergic reactions.
Efforts are underway to develop vaccines that can mitigate allergic reactions caused by cat flea allergen proteins. These vaccines aim to desensitize the immune system to the allergens. By introducing small, controlled amounts of the allergen proteins over time, the body gradually becomes less responsive to them, reducing the severity of allergic symptoms.
Currently, the primary treatment for cat allergies is allergen avoidance, which often involves limiting exposure to cats and frequent cleaning. However, for many, complete avoidance is impractical or undesirable. Antihistamines and corticosteroids can help alleviate symptoms, but they do not provide a long-term solution.
Innovative approaches like allergen-specific immunotherapy are being explored. This involves administering small, increasing doses of the allergen proteins to patients, gradually desensitizing their immune systems. While promising, this treatment is still in the experimental phase and requires further research.
Creative BioMart offers a comprehensive range of high-quality cat flea allergen-related protein products, including essential proteins like Cte f 2, Cte f 3, Cul q 2, and Cte f 1. Whether you're conducting allergy research, diagnostic development, vaccine studies, or therapeutic investigations, our proteins can provide valuable insights and solutions. Contact us and explore our extensive selection today to advance your studies in this critical field.
