Apricots, with their sweet and tangy flavor, are enjoyed by many. However, for some individuals, the consumption of apricots can lead to allergic reactions. These reactions are triggered by specific proteins found in apricots, known as apricot allergen proteins. The main culprits in apricot allergy are Pru ar 1, Pru ar 3, Pru ar 5, and Pru m 7.
Apricot allergen proteins belong to various molecular families, but the key players fall into the Pru ar group. Pru ar 1 is a major allergen found in apricots, known for its role in allergic responses. It is classified as a lipid transfer protein, exhibiting structural characteristics that make it recognizable by the immune system.
Pru ar 3, another prominent apricot allergen, belongs to the Bet v 1 family. This family includes proteins involved in plant defense mechanisms. Pru ar 5 is a thaumatin-like protein, known for its allergenic properties. Pru m 7, on the other hand, belongs to the profilin family, a group of proteins involved in cytoskeleton dynamics.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3771P | Recombinant Pru ar 1 | Prunus armeniaca (Apricot) | E.coli or Yeast | His |
| ra-3772P | Recombinant Pru ar 3 | Prunus armeniaca (Apricot) | E.coli or Yeast | His |
| ra-3773P | Recombinant Pru ar 5 | Prunus armeniaca (Apricot) | E.coli or Yeast | His |
| ra-3786P | Recombinant Pru m 7 | Prunus mume (Japanese apricot) | E.coli or Yeast | His |
The biological functions of apricot allergen proteins go beyond their role in causing allergic reactions. Pru ar 1, being a lipid transfer protein, plays a crucial role in lipid metabolism within apricot cells. However, when introduced into the human body, it can trigger an immune response leading to allergic symptoms.
Pru ar 3, belonging to the Bet v 1 family, is involved in the plant's defense against pathogens. Its presence in apricots can lead to cross-reactivity with other plant allergens, causing allergic sensitivities in susceptible individuals. Pru ar 5, the thaumatin-like protein, also contributes to the plant's defense mechanisms, but its allergenic nature makes it a concern for allergic reactions.
The molecular mechanisms underlying apricot allergies involve the recognition of these allergen proteins by the immune system. When an allergic individual consumes apricots, the immune system identifies these proteins as harmful, leading to the release of histamines and other chemicals that cause allergic symptoms.
Despite their role in allergies, apricot allergen proteins have found applications in biomedicine. Researchers are exploring these proteins for diagnostic development, vaccine development, and potential treatment options.
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