What is Olive Allergen

Olive allergens are proteins found in olives that can trigger an allergic response in susceptible individuals. These proteins belong to the broader molecular family of allergens, with distinct structural characteristics that set them apart. Understanding the classification of olive allergen proteins is crucial for comprehending their role in allergies.

Olive Allergen Proteins: Composition and Classification

Olive allergen proteins primarily include Ole e 1, Ole e 2, and Ole e 3, each classified under different molecular families. Ole e 1, for instance, belongs to the pathogenesis-related protein 10 (PR-10) family. Ole e 2 falls under the cupin superfamily, while Ole e 3 is part of the non-specific lipid transfer protein (nsLTP) family. These structural variances contribute to the allergenicity of olives and play a pivotal role in their biological functions.

Our Featured Olive Allergens

Cat.No.	Product Name	Species	Source	Tag
ra-3728PB	Recombinant Ole e 1, Biotin Labeled	Olive	E.coli	His
ra-3728P	Recombinant Ole e 1	Olive	E.coli	His
ra-3737P	Recombinant Ole e 10	Olea europaea (Olive)	E.coli or Yeast	His
ra-3738P	Recombinant Ole e 11	Olea europaea (Olive)	E.coli or Yeast	His
ra-3739P	Recombinant Ole e 12	Olea europaea (Olive)	E.coli or Yeast	His
ra-3740P	Recombinant Ole e 13	Olea europaea (Olive)	E.coli or Yeast	His
ra-3741P	Recombinant Ole e 14	Olea europaea (Olive)	E.coli or Yeast	His
ra-3742P	Recombinant Ole e 15	Olea europaea (Olive)	E.coli or Yeast	His
ra-3729PB	Recombinant Ole e 2, Biotin Labeled	Olive	E.coli	His
ra-3729P	Recombinant Ole e 2	Olive	E.coli	His
ra-3730P	Recombinant Ole e 3	Olea europaea (Olive)	E.coli or Yeast	His
ra-3731P	Recombinant Ole e 4	Olea europaea (Olive)	E.coli or Yeast	His
ra-3732PB	Recombinant Ole e 5, Biotin Labeled	Olea europaea (Olive)	E.coli	His
ra-3732P	Recombinant Ole e 5	Olea europaea (Olive)	E.coli	His
ra-3733P	Recombinant Ole e 6	Olea europaea (Olive)	E.coli or Yeast	His
ra-3734PB	Recombinant Ole e 7,partial, Biotin Labeled	Olea europaea	E.coli
ra-3734P	Recombinant Ole e 7,partial	Olea europaea	E.coli
ra-3735P	Recombinant Ole e 8	Olea europaea (Olive)	E.coli or Yeast	His
ra-3736P	Recombinant Ole e 9	Olea europaea (Olive)	E.coli or Yeast	His

Olive Allergen Biological Functions and Allergic Responses

Olive allergen proteins serve essential functions within the olive plant, contributing to its defense mechanisms and overall survival. Ole e 1, being a PR-10 protein, is involved in the response to pathogenic attacks. Ole e 2, a member of the cupin superfamily, is associated with lipid binding and metabolism, while Ole e 3, an nsLTP, participates in lipid transfer processes.

Allergy to olives is often a result of the immune system mistakenly identifying olive allergen proteins as harmful. Upon exposure, these proteins can induce an allergic response, leading to symptoms ranging from mild itching to severe anaphylaxis. The molecular mechanisms behind olive allergies involve the recognition of these proteins by the immune system, triggering the release of histamines and other inflammatory mediators. Understanding these mechanisms is crucial for developing effective diagnostic and treatment strategies.

Applications of Olive Allergen Proteins in Biomedicine

Diagnostic Development: Olive allergen proteins play a pivotal role in the development of diagnostic tools for identifying individuals with olive allergies. Immunological assays, such as enzyme-linked immunosorbent assays (ELISA) and skin prick tests, utilize these proteins to detect specific IgE antibodies indicative of an allergic response. Accurate diagnosis is the first step towards effective management of olive allergies.
Vaccine Development: Exploring olive allergen proteins opens avenues for vaccine development to mitigate allergic reactions. Allergen-specific immunotherapy (AIT) aims to desensitize the immune system to these proteins, reducing the severity of allergic symptoms. Vaccines based on modified forms of olive allergens can help train the immune system to tolerate exposure without triggering an allergic response.
Treatment Strategies: The insights gained from studying olive allergen proteins also contribute to the development of targeted treatment strategies. Anti-allergic medications, such as antihistamines and corticosteroids, aim to alleviate symptoms by modulating the immune response. Additionally, identifying specific epitopes on these proteins allows for the development of more precise and efficient therapeutic interventions.