Fish, renowned for its status as a widely embraced and nutritionally rich food source, paradoxically serves as a potential source of unease and peril for a specific segment of the population. This juxtaposition arises from the presence of fish allergen proteins, the culprits behind the induction of allergic responses in those who are susceptible to them. In the ensuing segments of this article, we shall embark on a comprehensive exploration of the intricate realm of fish allergen proteins.
The main constituents of fish allergen proteins are predominantly parvalbumins, a subgroup of calcium-binding proteins that govern the structural and functional characteristics of fish muscle tissues. These allergenic proteins can be categorized into two main groups: Type I and Type II parvalbumins. Type I parvalbumins are found in species like cod, while Type II parvalbumins are present in salmon and trout. These proteins share similar structural characteristics, characterized by their compact three-dimensional structures and high calcium-binding capacity.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3323A | Recombinant Clu h 1 | Clupea harengus (Atlantic herring) | E.coli or Yeast | His |
| ra-3326A | Recombinant Cten i 1 | Ctenopharyngodon idella (Grass carp) | E.coli or Yeast | His |
| ra-3327A | Recombinant Cyp c 1 | Cyprinus carpio (Common carp) | E.coli or Yeast | His |
| ra-3327AE1 | Recombinant Cyp c 1.02 | Cyprinus carpio | E.coli | |
| ra-3327AE1B | Recombinant Cyp c 1.02, Biotin Labeled | Cyprinus carpio | E.coli | |
| ra-3328A | Recombinant Cyp c 2 | Cyprinus carpio (Common carp) | E.coli or Yeast | His |
| ra-3344A | Recombinant Gad c 1 | Gadus callarias (Baltic cod) | E.coli | His |
| ra-3344AB | Recombinant Gad c 1, Biotin Labeled | Gadus callarias (Baltic cod) | E.coli | His |
| ra-3345A | Recombinant Gad m 1 | Gadus morhua (Atlantic cod) | E.coli or Yeast | His |
| ra-3346A | Recombinant Gad m 2 | Gadus morhua (Atlantic cod) | E.coli or Yeast | His |
| ra-3347A | Recombinant Gad m 3 | Gadus morhua (Atlantic cod) | E.coli or Yeast | His |
| ra-3363A | Recombinant Lat c 1 | Lates calcarifer (Barramundi) | E.coli or Yeast | His |
| ra-3364A | Recombinant Lat c 6 | Lates calcarifer (Barramundi) | E.coli or Yeast | His |
| ra-3177A | Recombinant Lep s 1 | Lepisma saccharina (Silverfish) | E.coli or Yeast | His |
| ra-3365A | Recombinant Lep w 1 | Lepidorhombus whiffiagonis (Megrim, whiff, turbot fish) | E.coli or Yeast | His |
| ra-3368A | Recombinant Onc k 5 | Oncorhynchus keta (Chum salmon) | E.coli or Yeast | His |
| ra-3369A | Recombinant Onc m 1 | Oncorhynchus mykiss (Rainbow trout) | E.coli or Yeast | His |
| ra-3370A | Recombinant Ore m 4 | Oreochromis mossambicus (Mozambique tilapia) | E.coli or Yeast | His |
| ra-3374A | Recombinant Pan h 1 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3381A | Recombinant Pan h 10 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3382A | Recombinant Pan h 11 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3383A | Recombinant Pan h 13 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3375A | Recombinant Pan h 2 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3376A | Recombinant Pan h 3 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3377A | Recombinant Pan h 4 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3378A | Recombinant Pan h 7 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3379A | Recombinant Pan h 8 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3380A | Recombinant Pan h 9 | Pangasianodon hypophthalmus (Striped catfish) | E.coli or Yeast | His |
| ra-3387A | Recombinant Ras k 1 | Rastrelliger kanagurta (Indian mackerel) | E.coli or Yeast | His |
| ra-3389A | Recombinant Sal s 1 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3390A | Recombinant Sal s 2 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3391A | Recombinant Sal s 3 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3392A | Recombinant Sal s 4 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3393A | Recombinant Sal s 6 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3394A | Recombinant Sal s 7 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3395A | Recombinant Sal s 8 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3396A | Recombinant Sal s 9 | Salmo salar (Atlantic salmon) | E.coli or Yeast | His |
| ra-3397A | Recombinant Sar sa 1 | Sardinops sagax (Pacific pilchard) | E.coli or Yeast | His |
| ra-3398A | Recombinant Sco s 1 | Scomber scombrus (Atlantic mackerel) | E.coli or Yeast | His |
| ra-3399A | Recombinant Seb m 1 | Sebastes marinus (Ocean perch, redfish, snapper) | E.coli or Yeast | His |
| ra-3401A | Recombinant Thu a 1 | Thunnus albacares (Yellowfin tuna) | E.coli or Yeast | His |
| ra-3402A | Recombinant Thu a 2 | Thunnus albacares (Yellowfin tuna) | E.coli or Yeast | His |
| ra-3403A | Recombinant Thu a 3 | Thunnus albacares (Yellowfin tuna) | E.coli or Yeast | His |
| ra-3404A | Recombinant Xip g 1 | Xiphias gladius (Swordfish) | E.coli or Yeast | His |
Parvalbumins play a vital role in fish muscle tissues by regulating calcium levels and muscle contraction. However, for individuals with fish allergies, exposure to these proteins can trigger allergic reactions. Allergy to fish typically manifests as skin reactions, gastrointestinal symptoms, respiratory distress, or even anaphylaxis in severe cases.
The molecular mechanisms underlying fish allergies involve the immune system's recognition of parvalbumins as foreign invaders. When a person with a fish allergy consumes fish or comes into contact with fish proteins, their immune system mistakenly identifies parvalbumins as harmful substances. This triggers the release of histamines and other immune mediators, leading to the characteristic symptoms of an allergic reaction.
Fish allergen proteins have proven invaluable in the development of diagnostic tests for fish allergies. Specific IgE blood tests and skin prick tests are commonly used to diagnose fish allergies. These tests use purified fish allergen proteins, including parvalbumins, to detect the presence of allergen-specific antibodies in a patient's blood or to elicit an allergic skin reaction. Accurate diagnosis is crucial for individuals with fish allergies to avoid potentially life-threatening allergic reactions.
Researchers are exploring the development of vaccines to desensitize individuals with fish allergies. These vaccines aim to train the immune system to tolerate fish allergen proteins without triggering an allergic response. By using modified forms of parvalbumins or other immunotherapy approaches, scientists are working towards providing long-term relief to fish allergy sufferers.
Currently, the primary treatment for fish allergies is strict avoidance of fish and fish products. However, accidental exposures can still occur. In such cases, antihistamines and epinephrine may be administered to manage allergic reactions. With ongoing research in the field of immunotherapy and vaccine development, more targeted and effective treatments may become available in the future.
Creative BioMart offers a comprehensive range of fish allergen-related protein products to support your research needs. Our high-quality proteins are meticulously characterized and designed to facilitate studies on fish allergens, helping you advance your research in allergen identification, diagnosis, and therapeutic development. Contact us and explore our diverse portfolio of fish allergen proteins today and accelerate your allergy research with confidence.
