Beetle allergen proteins encompass a diverse group of allergenic molecules derived from various beetle species. In this article, we delve into the world of beetle allergen proteins, with a specific focus on Harmonia axyridis (Asian ladybeetle)'s Har a 1 allergenic protein. These proteins are a significant subset of beetle allergens, sharing structural homology with other arthropod allergenic proteins. We will explore their structural characteristics, biological functions, and the pivotal role they play in allergic responses and allergies as a whole.
Beetle allergen proteins, characterized by their distinctive three-dimensional structures, are primarily composed of small, stable proteins with a variety of functions. These allergens typically belong to the cysteine-rich protein family, with cysteine residues forming disulfide bridges crucial for their stability. The molecular weight of beetle allergen proteins varies, but they commonly fall within the range of 10 to 30 kilodaltons.
Harmonia axyridis (Asian ladybeetle)'s Har a 1 allergenic protein, like other beetle allergen proteins, is characterized by its distinctive three-dimensional structure. These allergens typically belong to the cysteine-rich protein family, with cysteine residues forming disulfide bridges crucial for their stability. The molecular weight of Har a 1 and similar beetle allergen proteins varies but commonly falls within the range of 10 to 30 kilodaltons. Such structural features contribute to their allergenicity and potential cross-reactivity with allergenic proteins from other sources, complicating allergy diagnosis and management.
| Cat.No. | Product Name | Species | Source | Tag |
| ra-3167A | Recombinant Har a 1 | Harmonia axyridis (Asian ladybeetle) | E.coli or Yeast | His |
| ra-3168A | Recombinant Har a 2 | Harmonia axyridis (Asian ladybeetle) | E.coli or Yeast | His |
The biological functions of beetle allergen proteins are not entirely understood, but they are believed to play a crucial role in the insect's physiology, possibly involved in digestion, immunity, or protection against environmental stressors. However, when these proteins come into contact with humans, they can trigger allergic responses.
Allergic reactions to beetle allergen proteins typically manifest as respiratory or skin allergies. Upon exposure, the immune system recognizes these proteins as foreign invaders and mounts an immune response. This response involves the production of IgE antibodies, which bind to the allergen proteins. Subsequent encounters with the allergen lead to the release of histamines and other inflammatory mediators, resulting in symptoms such as sneezing, itching, and even severe anaphylactic reactions in extreme cases.
Understanding the role of beetle allergen proteins is crucial for diagnostic development, vaccine creation, and allergy treatment. Here's how these proteins are influencing these areas:
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