What is Peach Allergen

Peaches, with their sweet and succulent taste, are a popular fruit enjoyed worldwide. However, for some individuals, the innocent-looking peach can be a source of allergic reactions. The culprit behind these allergies lies in the intricate world of peach allergen proteins.

Peach allergens are proteins found in peaches that trigger allergic reactions in susceptible individuals. These proteins belong to the Pru p (Prunus persica) family, named after the scientific classification of the peach plant. Within this family, several allergenic proteins have been identified, each with unique structural characteristics. The major peach allergen proteins include Pru p 1, Pru p 3, and Pru p 4.

Peach Allergen Proteins: Composition and Classification

Pru p 1: This protein belongs to the pathogenesis-related protein 10 (PR-10) family and is known for its role in plant defense mechanisms. Pru p 1 exhibits a compact and stable structure, consisting of a β-barrel motif with a hydrophobic cavity that binds small ligands. Its allergenic properties stem from its ability to interact with the human immune system, triggering allergic responses.
Pru p 3: As a lipid transfer protein (LTP), Pru p 3 plays a crucial role in lipid metabolism within the peach plant. Structurally, it features an eight-stranded antiparallel β-sheet and a hydrophobic cavity, facilitating the transfer of lipids. Individuals allergic to Pru p 3 may experience adverse reactions due to its immunogenic properties.
Pru p 4: Classified as a profilin, Pru p 4 is involved in the regulation of actin dynamics in plant cells. Profilins are known for their ability to bind actin monomers, influencing cell shape and movement. Pru p 4's allergenicity arises from its cross-reactivity with homologous proteins in other fruits and pollens.

Our Featured Peach Allergens

Cat.No.	Product Name	Species	Source	Tag
ra-3787P	Recombinant Pru p 1	Peach	E.coli	His
ra-3788P	Recombinant Pru p 2	Prunus persica (Peach)	E.coli or Yeast	His
ra-3789P	Recombinant Pru p 3	Prunus persica (Peach)	E.coli	His-Sumo
ra-3790P	Recombinant Pru p 4	Peach	E.coli	His
ra-3791P	Recombinant Pru p 7	Prunus persica (Peach)	E.coli or Yeast	His
ra-3792P	Recombinant Pru p 9	Prunus persica (Peach)	E.coli or Yeast	His
ra-3787PE1	Recombinant Pru p 1.01	Prunus dulcis x Prunus persica	E.coli
ra-3787PB	Recombinant Pru p 1, Biotin Labeled	Peach	E.coli	His
ra-3790PB	Recombinant Pru p 4, Biotin Labeled	Peach	E.coli	His
ra-3787PE1B	Recombinant Pru p 1.01, Biotin Labeled	Prunus dulcis x Prunus persica	E.coli
ra-3789PB	Recombinant Pru p 3, Biotin Labeled	Prunus persica (Peach)	E.coli	His-Sumo

Peach Allergen Biological Functions and Allergic Responses

Peach allergen proteins serve essential biological functions within the peach plant, contributing to its growth, development, and defense mechanisms. However, when introduced into the human body, these proteins can elicit allergic responses. The biological functions of key peach allergen proteins include:

Pru p 1: This PR-10 protein is involved in the plant's defense against pathogens. Its immunomodulatory properties, when encountered by the human immune system, can lead to the development of allergic symptoms such as itching, swelling, and respiratory distress.
Pru p 3: As a lipid transfer protein, Pru p 3 participates in lipid metabolism in peach cells. When consumed by individuals with a predisposition to LTP allergies, it can induce allergic reactions, causing symptoms such as gastrointestinal distress, skin rashes, and in severe cases, anaphylaxis.
Pru p 4: Profilins, including Pru p 4, play a role in regulating the plant's cytoskeleton. Cross-reactivity with homologous proteins in other fruits and pollens can lead to allergic sensitivities, resulting in symptoms ranging from mild oral allergy syndrome to more severe reactions.

The allergic response to peach allergens is a result of the immune system's misidentification of these proteins as harmful invaders. Upon exposure, the immune system produces immunoglobulin E (IgE) antibodies specific to peach allergen proteins, leading to the release of histamine and other inflammatory mediators. This cascade of events causes the allergic symptoms experienced by individuals, ranging from mild itching and swelling to severe anaphylactic reactions.

The molecular mechanisms underlying peach allergies involve the interaction between peach allergen proteins and the immune system. Pru p 1, Pru p 3, and Pru p 4 activate immune cells, such as mast cells and basophils, triggering the release of histamine. This histamine release results in the classic symptoms of allergies, including itching, redness, and swelling. In severe cases, the systemic release of histamine can lead to anaphylaxis, a life-threatening allergic reaction requiring immediate medical attention.

Applications of Peach Allergen Proteins in Biomedicine

Diagnostic Development: Peach allergen proteins, with their well-defined structures and immunogenic properties, serve as valuable tools in the development of diagnostic tests for identifying peach allergies. Allergen-specific IgE tests can help clinicians accurately diagnose and manage allergic conditions, enabling personalized treatment plans for affected individuals.
Vaccine Development: Understanding the molecular details of peach allergen proteins provides insights into developing allergy vaccines. Immunotherapy involving desensitization to peach allergens may offer a long-term solution for individuals with severe allergies, helping them build tolerance and reduce the risk of allergic reactions upon peach exposure.
Treatment Strategies: Targeting peach allergen proteins in the development of novel therapeutic strategies holds promise for managing allergic reactions. By blocking the interaction between allergens and immune cells, researchers aim to mitigate the severity of allergic symptoms and improve the quality of life for individuals with peach allergies.